A new synthetic strategy to get the PNA–3′DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed. The synthetic strategies take advantage of the introduction of the acid-labile Mmt-protecting group in the first step.
New synthesis of PNA-3'DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras / Musumeci, Domenica; Giovanni N., Roviello; Margherita, Valente; Roberto, Sapio; Pedone, Carlo; Enrico M., Bucci. - In: BIOPOLYMERS. - ISSN 0006-3525. - STAMPA. - 76:(2004), pp. 535-542. [10.1002/bip.20135]
New synthesis of PNA-3'DNA linker monomers, useful building blocks to obtain PNA/DNA chimeras
MUSUMECI, DOMENICA;PEDONE, CARLO;
2004
Abstract
A new synthetic strategy to get the PNA–3′DNA linker with the monomethoxytrityl (Mmt) group as temporary protection of the backbone to be used for the synthesis of PNA/DNA chimeras was employed and a convenient strategy to obtain Mmt PNA monomers was developed. The synthetic strategies take advantage of the introduction of the acid-labile Mmt-protecting group in the first step.| File | Dimensione | Formato | |
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