Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species pro- duction in some patients affected by severe photoaging and actinic keratosis
Effects of a New Human Recombinant MnSOD in the Treatment of Photoaging and Actinic Keratosis / RUGGIERO MARIA, Grazia; POLLIO MARIA, Laura; Schiattarella, Antonietta; Borrelli, Antonella; Mancini, Aldo; Pica, Alessandra; Forgione, P. A. T. R. I. Z. I. A.. - In: JOURNAL OF CANCER THERAPY. - ISSN 2151-1942. - 4:(2013), pp. 56-59. [10.4236/jct.2013.46A1009]
Effects of a New Human Recombinant MnSOD in the Treatment of Photoaging and Actinic Keratosis.
PICA, ALESSANDRA;
2013
Abstract
Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species pro- duction in some patients affected by severe photoaging and actinic keratosisI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.