The expression of calcium/calmodulin-dependent kinase IV (CaMKIV) was hitherto thought to be confined to the nervous system. However, a recent genome-wide analysis indicated an association between hypertension and a single-nucleotide polymorphism (rs10491334) of the human CaMKIV gene (CaMK4), which suggests a role for this kinase in the regulation of vascular tone.
CaMK4 Gene Deletion Induces Hypertension / Santulli, Gaetano; Cipolletta, E; Sorriento, Daniela; Del Giudice, C; Anastasio, A; Monaco, S; Maione, As; Condorelli, G; Puca, A; Trimarco, Bruno; Illario, Maddalena; Iaccarino, G.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 1:4(2012), p. e001081. [10.1161/JAHA.112.001081]
CaMK4 Gene Deletion Induces Hypertension.
SANTULLI, GAETANO;SORRIENTO, DANIELA;TRIMARCO, BRUNO;ILLARIO, MADDALENA;Iaccarino G.
2012
Abstract
The expression of calcium/calmodulin-dependent kinase IV (CaMKIV) was hitherto thought to be confined to the nervous system. However, a recent genome-wide analysis indicated an association between hypertension and a single-nucleotide polymorphism (rs10491334) of the human CaMKIV gene (CaMK4), which suggests a role for this kinase in the regulation of vascular tone.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
