The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypothyroidism, consequent to a reduced gland size and a deranged differentiation. These results demonstrate that Pax8 is also an essential player in controlling survival and differentiation of adult thyroid follicular cells. © 2014 Elsevier Ireland Ltd.
The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells / Marotta, P; Amendola, E; Scarfò, M; De Luca, P; Zoppoli, P; Amoresano, Angela; DE FELICE, Mario; DI LAURO, Roberto. - In: MOLECULAR AND CELLULAR ENDOCRINOLOGY. - ISSN 0303-7207. - 396:(2014), pp. 26-36. [10.1016/j.mce.2014.08.004]
The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
Zoppoli P;AMORESANO, ANGELA;DE FELICE, MARIO;DI LAURO, ROBERTO
2014
Abstract
The transcription factor Pax8 is already known to be essential at very early stages of mouse thyroid gland development, before the onset of thyroid hormone production. In this paper we show, using a conditional inactivation strategy, that the removal of the Pax8 protein late in gland development results in severe hypothyroidism, consequent to a reduced gland size and a deranged differentiation. These results demonstrate that Pax8 is also an essential player in controlling survival and differentiation of adult thyroid follicular cells. © 2014 Elsevier Ireland Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
