The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery
Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development / Imperatore, Concetta; Aiello, Anna; D'Aniello, Filomena; Maria, Senese; Menna, Marialuisa. - In: MOLECULES. - ISSN 1420-3049. - 19:12(2014), pp. 20391-20423. [10.3390/molecules191220391]
Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development
IMPERATORE, CONCETTA;AIELLO, ANNA;D'ANIELLO, FILOMENA;MENNA, MARIALUISA
2014
Abstract
The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discoveryI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
