The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH / Miranda, Km; Dutton, As; Ridnour, La; Foreman, Ca; Ford, E; Paolocci, N; Katori, T; Tocchetti, CARLO GABRIELE; Mancardi, D; Thomas, Dd; Espey, Mg; Houk, Kn; Fukuto, Jm; Wink, Da. - In: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. - ISSN 0002-7863. - 127:2(2005), pp. 722-731. [10.1021/ja045480x]
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH
TOCCHETTI, CARLO GABRIELE;
2005
Abstract
The recent determination that Angeli's salt may have clinical application as a nitrogen oxide donor for treatment of cardiovascular diseases such as heart failure has led to renewed interest in the mechanism and products of thermal decomposition of Angeli's salt under physiological conditions. In this report, several mechanisms are evaluated experimentally and by quantum mechanical calculations to determine whether HNO is in fact released from Angeli's salt in neutral, aerobic solution. The mechanism of product autoxidation is also considered.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
