Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders.
Immunopharmacological modulation of mast cells / Borriello, Francesco; Granata, F.; Varricchi, Gilda; Genovese, Arturo; Triggiani, M.; Marone, Gianni. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 17:(2014), pp. 45-57. [10.1016/j.coph.2014.07.002]
Immunopharmacological modulation of mast cells
BORRIELLO, FRANCESCO;VARRICCHI, GILDA;GENOVESE, ARTURO;MARONE, GIANNI
2014
Abstract
Mast cells produce a wide spectrum of mediators and they have been implicated in several physiopathological conditions (e.g. allergic reactions and certain tumors). Pharmacologic agents that modulate the release of mediators from mast cells has helped to elucidate the biochemical mechanisms by which immunological and non-immunological stimuli activate these cells. Furthermore, the study of surface receptors and signaling pathways associated with mast cell activation revealed novel pharmacologic targets. Thus, the development of pharmacologic agents based on this new wave of knowledge holds promise for the treatment of several mast cell-mediated disorders.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
