A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.
Identification of novel interactors of human telomeric G-quadruplex DNA / Pagano, B., L., M., P., Z., Amato, J., Iaccarino, N., C., C., E., S., Novellino, E., A., B., A., C., Randazzo, A.. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 51:14(2015), pp. 2964-2967. [10.1039/c4cc07231f]
Identification of novel interactors of human telomeric G-quadruplex DNA
PAGANO, BRUNO
Primo
;AMATO, JUSSARA;IACCARINO, NUNZIA;NOVELLINO, ETTORE;RANDAZZO, ANTONIOUltimo
2015
Abstract
A chemoproteomic-driven approach was used to investigate the interaction network between human telomeric G-quadruplex DNA and nuclear proteins. We identified novel G-quadruplex binding partners, able to recognize these DNA structures at chromosome ends, suggesting a possible, and so far unknown, role of these proteins in telomere functions.File in questo prodotto:
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