Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major in patients with CLI and improving their quality of life.
Cell Therapy in Patients with Critical Limb Ischemia / Compagna, Rita; Amato, Bruno; Massa, Salvatore; Amato, Maurizio; Grande, Raffaele; Butrico, Lucia; Stefano de Franciscis, ; Serra, Raffaele. - In: STEM CELLS INTERNATIONAL. - ISSN 1687-9678. - 2015:(2015), pp. 1-13. [10.1155/2015/931420]
Cell Therapy in Patients with Critical Limb Ischemia
Rita Compagna;Bruno Amato;Salvatore Massa;Maurizio Amato;SERRA, RAFFAELE
2015
Abstract
Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenous molecular and cellular agents to promote regeneration of the vasculature. These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major in patients with CLI and improving their quality of life.File | Dimensione | Formato | |
---|---|---|---|
cell therapy in patients with cli 931420.pdf
non disponibili
Descrizione: articolo principale
Tipologia:
Documento in Post-print
Licenza:
Accesso privato/ristretto
Dimensione
1.3 MB
Formato
Adobe PDF
|
1.3 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.