In patients with chronic HCV-1 infection, recent evidences indicate that determination of a dinucleotide polymorphism (ss469415590, ΔG/TT) of a new gene, designated IFN λ-4, might be more accurate than the 12979860CC type of the IL28B locus in predicting sustained virological response (SVR) following peg-interferon and ribavirin. In addition, combined genotyping of different SNPs of the IL28B locus was shown to help dissect patients most prone to SVR among those with rs12979860CT. We examined whether single or combined genotyping of two IL28B SNPs, rs12979860 and rs8099917, and ss469415590 variation might improve the prediction of SVR.
Variation in genes encoding for interferon λ-3 and λ-4 in the prediction of HCV-1 treatment-induced viral clearance / Palmieri, Orazio; Ippolito, Antonio M; Margaglione, Maurizio; Valvano, Maria Rosa; Gioffreda, Domenica; Fasano, Massimo; D'Andrea, Giovanna; Corritore, Giuseppe; Milella, Michele; Andriulli, Nicola; Morisco, Filomena; Giannitrapani, Lydia; Latiano, Anna; Fontana, Rosanna; Gatti, Pietro; Tundo, Paolo; Barone, Michele; Cozzolongo, Raffaele; Santantonio, Teresa; Andriulli, Angelo. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - 34:9(2014), pp. 1369-77-1377. [10.1111/liv.12411]
Variation in genes encoding for interferon λ-3 and λ-4 in the prediction of HCV-1 treatment-induced viral clearance
Valvano, Maria Rosa;MORISCO, FILOMENA;BARONE, MICHELE;
2014
Abstract
In patients with chronic HCV-1 infection, recent evidences indicate that determination of a dinucleotide polymorphism (ss469415590, ΔG/TT) of a new gene, designated IFN λ-4, might be more accurate than the 12979860CC type of the IL28B locus in predicting sustained virological response (SVR) following peg-interferon and ribavirin. In addition, combined genotyping of different SNPs of the IL28B locus was shown to help dissect patients most prone to SVR among those with rs12979860CT. We examined whether single or combined genotyping of two IL28B SNPs, rs12979860 and rs8099917, and ss469415590 variation might improve the prediction of SVR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
