Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes.
Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy / BERNI CANANI, Roberto; Paparo, Lorella; Nocerino, Rita; Cosenza, Linda; Pezzella, Vincenza; DI COSTANZO, Margherita; Capasso, Mario; DEL MONACO, Valentina; D'Argenio, Valeria; Greco, Luigi; Salvatore, Francesco. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - 10:1(2015), pp. 38-45. [10.1186/s13148-015-0070-8]
Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy
BERNI CANANI, ROBERTO;PAPARO, LORELLA;NOCERINO, RITA;COSENZA, LINDA;DI COSTANZO, MARGHERITA;CAPASSO, Mario;DEL MONACO, VALENTINA;D'ARGENIO, VALERIA;GRECO, LUIGI;SALVATORE, FRANCESCO
2015
Abstract
Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes.| File | Dimensione | Formato | |
|---|---|---|---|
|
Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy.pdf
accesso aperto
Tipologia:
Documento in Post-print
Licenza:
Dominio pubblico
Dimensione
819.93 kB
Formato
Adobe PDF
|
819.93 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
