A highly convergent multistep process incorporating an aza-Achmatowicz rearrangement has been described, selectively providing enantiomerically pure bicyclic (dihydro)furans 9 and 18 as well as the tricyclic dihydropyridinone 23 from acyclic starting materials after up to eight sequential synthetic transformations in one step.
Beyond Achmatowicz reaction: DDQ-mediated chemo- and stereoconvergent domino-one pot cyclization/rearrangement of bis-thioenol ether-containing chiral building blocks / Guaragna, Annalisa; Dell'Isola, Antonio; D'Errico, Stefano; Palumbo, Giovanni; D'Alonzo, Daniele. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - 55:51(2014), pp. 7007-7010. [10.1016/j.tetlet.2014.10.113]
Beyond Achmatowicz reaction: DDQ-mediated chemo- and stereoconvergent domino-one pot cyclization/rearrangement of bis-thioenol ether-containing chiral building blocks
GUARAGNA, ANNALISA;D'ERRICO, STEFANO;PALUMBO, GIOVANNI;D'ALONZO, DANIELE
2014
Abstract
A highly convergent multistep process incorporating an aza-Achmatowicz rearrangement has been described, selectively providing enantiomerically pure bicyclic (dihydro)furans 9 and 18 as well as the tricyclic dihydropyridinone 23 from acyclic starting materials after up to eight sequential synthetic transformations in one step.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
