Microfluidics combined with X-ray scattering techniques allows probing conformational changes or assembly processes of biological materials. Our aim was to develop a highly X-ray transparent microfluidic cell for detecting small variations of X-ray scattering involved in such processes. We describe the fabrication of a polyimide microfluidic device based on a simple, reliable and inexpensive lamination process. The implemented microstructured features result in windows with optimized X-ray transmission. The microfluidic device was characterized by X-ray microbeam scattering at the ID13 beamline of the European Synchrotron Radiation Facility.
Optimized fabrication protocols of microfluidic devices for X-ray analysis / Catalano, Rossella; Perozziello, Gerardo; Simone, Giuseppina; Candeloro, Patrizio; Gentile, Francesco; Coluccio, Maria Laura; Pardeo, Francesca; Burghammer, Manfred; Cuda, Giovanni; Riekel, Christian; Di Fabrizio, Enzo. - In: MICROELECTRONIC ENGINEERING. - ISSN 0167-9317. - 124:(2014), pp. 13-16. [10.1016/j.mee.2014.04.016]
Optimized fabrication protocols of microfluidic devices for X-ray analysis
GENTILE, Francesco;
2014
Abstract
Microfluidics combined with X-ray scattering techniques allows probing conformational changes or assembly processes of biological materials. Our aim was to develop a highly X-ray transparent microfluidic cell for detecting small variations of X-ray scattering involved in such processes. We describe the fabrication of a polyimide microfluidic device based on a simple, reliable and inexpensive lamination process. The implemented microstructured features result in windows with optimized X-ray transmission. The microfluidic device was characterized by X-ray microbeam scattering at the ID13 beamline of the European Synchrotron Radiation Facility.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
