Background: In gastroesophageal reflux disease (GORD) patients, coexistence of functional dyspepsia (FD) is known to be associated with poor response to proton pump inhibitors (PPIs), but the contribution of specific dyspepsia symptoms has not been systematically investigated yet. Objective: To characterize the impact of dyspepsia symptoms on PPIs response in GORD patients. Methods:. The enrolled subjects were 100 patients with diagnosis of GORD. All patients underwent a 24 hour pH-impedance test, while on PPIs-therapy. Patients were divided into two groups, refractory and responders, according to the persistence of GORD symptoms. A standardized questionnaire for FD was also administered to assess presence of dyspepsia symptoms. Results: In the subgroup of refractory patients FD was more prevalent than in responder ones, with postprandial fullness, nausea, vomiting, early satiation and epigastric pain being significantly prevalent in refractory GORD-patients. In the multivariate analysis only early satiation and vomiting were significantly associated with poor response to PPIs Conclusion: Coexistence of FD is associated with refractory-GORD. We showed that only early satiation and vomiting are risk factors for poor response to PPIs therapy. Our findings suggest that symptoms of early satiation and vomiting would help to identify the subset of PPIs-refractory GORD patients.

SPECIFIC DYSPEPTIC SYMPTOMS ARE ASSOCIATED WITH POOR RESPONSE TO THERAPY IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE / D'Alessandro, Alessandra; Zito, FRANCESCO PAOLO; Andreozzi, Paolo; Pesce, Marcella; Efficie, Eleonora; Cargiolli, M; Maione, Francesco; DE PALMA, GIOVANNI DOMENICO; Cuomo, Rosario; Sarnelli, Giovanni. - In: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. - ISSN 2050-6414. - 5:1(2017), pp. 54-59. [10.1177/2050640616650061]

SPECIFIC DYSPEPTIC SYMPTOMS ARE ASSOCIATED WITH POOR RESPONSE TO THERAPY IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

D'ALESSANDRO, ALESSANDRA;ZITO, FRANCESCO PAOLO;ANDREOZZI, PAOLO;PESCE, MARCELLA;EFFICIE, ELEONORA;MAIONE, FRANCESCO;DE PALMA, GIOVANNI DOMENICO;CUOMO, ROSARIO;SARNELLI, GIOVANNI
2017

Abstract

Background: In gastroesophageal reflux disease (GORD) patients, coexistence of functional dyspepsia (FD) is known to be associated with poor response to proton pump inhibitors (PPIs), but the contribution of specific dyspepsia symptoms has not been systematically investigated yet. Objective: To characterize the impact of dyspepsia symptoms on PPIs response in GORD patients. Methods:. The enrolled subjects were 100 patients with diagnosis of GORD. All patients underwent a 24 hour pH-impedance test, while on PPIs-therapy. Patients were divided into two groups, refractory and responders, according to the persistence of GORD symptoms. A standardized questionnaire for FD was also administered to assess presence of dyspepsia symptoms. Results: In the subgroup of refractory patients FD was more prevalent than in responder ones, with postprandial fullness, nausea, vomiting, early satiation and epigastric pain being significantly prevalent in refractory GORD-patients. In the multivariate analysis only early satiation and vomiting were significantly associated with poor response to PPIs Conclusion: Coexistence of FD is associated with refractory-GORD. We showed that only early satiation and vomiting are risk factors for poor response to PPIs therapy. Our findings suggest that symptoms of early satiation and vomiting would help to identify the subset of PPIs-refractory GORD patients.
2017
SPECIFIC DYSPEPTIC SYMPTOMS ARE ASSOCIATED WITH POOR RESPONSE TO THERAPY IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE / D'Alessandro, Alessandra; Zito, FRANCESCO PAOLO; Andreozzi, Paolo; Pesce, Marcella; Efficie, Eleonora; Cargiolli, M; Maione, Francesco; DE PALMA, GIOVANNI DOMENICO; Cuomo, Rosario; Sarnelli, Giovanni. - In: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL. - ISSN 2050-6414. - 5:1(2017), pp. 54-59. [10.1177/2050640616650061]
File in questo prodotto:
File Dimensione Formato  
specific dyspeptic symptoms are associated UEGJ 2016.pdf

accesso aperto

Tipologia: Documento in Post-print
Licenza: Dominio pubblico
Dimensione 356.68 kB
Formato Adobe PDF
356.68 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/633249
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 9
  • ???jsp.display-item.citation.isi??? 5
social impact