Auoxo3, a cytotoxic gold(iii) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(i) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.

Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein / Ferraro, Giarita; Monti, DARIA MARIA; Amoresano, Angela; Pontillo, Nicola; Petruk, Ganna; Pane, Francesca; Cinellu, Maria Agostina; Merlino, Antonello. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 52:61(2016), pp. 9518-9521. [10.1039/c6cc02516a]

Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

FERRARO, GIARITA;MONTI, DARIA MARIA;AMORESANO, ANGELA;PETRUK, GANNA;PANE, FRANCESCA;MERLINO, ANTONELLO
2016

Abstract

Auoxo3, a cytotoxic gold(iii) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(i) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.
2016
Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein / Ferraro, Giarita; Monti, DARIA MARIA; Amoresano, Angela; Pontillo, Nicola; Petruk, Ganna; Pane, Francesca; Cinellu, Maria Agostina; Merlino, Antonello. - In: CHEMICAL COMMUNICATIONS. - ISSN 1364-548X. - 52:61(2016), pp. 9518-9521. [10.1039/c6cc02516a]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/636050
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