β-Thalassemia is a common inherited red cell disorder characterized by ineffective erythropoiesis and severe oxidative stress. Peroxiredoxin-2 (Prx2), a typical 2-cysteine peroxiredoxin, is upregulated during β-thalassemic erythropoiesis, but its contribution to stress erythropoiesis, a common feature of thalassemia, is yet to be fully defined.

The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis / Matte, Alessandro; DE FALCO, Luigia; Iolascon, Achille; Mohandas, Narla; An, Xiuli; Siciliano, Angela; Leboeuf, Christophe; Janin, Anne; Bruno, Mariasole; Choi, Soo Young; Kim, Dae Won; De Franceschi, Lucia. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - 23:16(2015), pp. 1284-97-1297. [10.1089/ars.2014.6237]

The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis

DE FALCO, LUIGIA;IOLASCON, ACHILLE;
2015

Abstract

β-Thalassemia is a common inherited red cell disorder characterized by ineffective erythropoiesis and severe oxidative stress. Peroxiredoxin-2 (Prx2), a typical 2-cysteine peroxiredoxin, is upregulated during β-thalassemic erythropoiesis, but its contribution to stress erythropoiesis, a common feature of thalassemia, is yet to be fully defined.
2015
The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis / Matte, Alessandro; DE FALCO, Luigia; Iolascon, Achille; Mohandas, Narla; An, Xiuli; Siciliano, Angela; Leboeuf, Christophe; Janin, Anne; Bruno, Mariasole; Choi, Soo Young; Kim, Dae Won; De Franceschi, Lucia. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - 23:16(2015), pp. 1284-97-1297. [10.1089/ars.2014.6237]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/638232
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