Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet. © 2014 Elsevier Ltd.
Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention / Vetrani, Claudia; Rivellese, ANGELA ALBAROSA; Annuzzi, Giovanni; Mattila, I. B; Meudec, E. C; Hyötyläinen, T. B; Orešič, M. B; Aura, A. M. b.. - In: FOOD RESEARCH INTERNATIONAL. - ISSN 0963-9969. - 63:(2014), pp. 233-238. [10.1016/j.foodres.2014.01.018]
Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention
VETRANI, CLAUDIA;RIVELLESE, ANGELA ALBAROSA;ANNUZZI, GIOVANNI;
2014
Abstract
Clinical trials are needed to confirm the association between polyphenol consumption and lower incidence of chronic diseases observed in epidemiological studies. However, a reliable evaluation of polyphenol intake is complicated. An 8-week randomized controlled trial (78 subjects) was performed using two isoenergetic diets differing only for polyphenol contents. Then, urinary phenolic metabolite profiles were analysed using gas-chromatography with mass detection. Phenolic metabolites detected in 24-h-urine were hydroxylated phenolic acids with C1-C3 side chain in the group consuming polyphenol-rich diet. The intake of polyphenol-rich foods increases the excretion of phenolic metabolites in urine providing a profile, which may serve as compliance biomarker of polyphenol-rich diet. © 2014 Elsevier Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
