On the basis of a previous equation correlating structural features and auxin-like activity, new sets of benzotriazole derivs. bearing in the position 1 or 2 a cycloalkyl residue, or substituents such as -CH(CH3)(CH2)n-COR', -CH(COR')(CH2)n-CH3, and -C(CH3)2 COR' (R' = OH, OEt; NH2) were prepd. and tested. An overall correlative equation which accommodates all the 106 benzotriazole derivs. was developed. Evidently, the bulkiness rather than asym. of the carbon attached to the heteroring nitrogen was responsible for extra activity. Moreover, structural features such as branching and -COR' group play an additive role only when the component parts of the N-substituent are properly structured.
Structure-activity relationships for the auxin-like activity of benzotriazole derivatives / Sparatore, F.; La Rotonda, M. I.; Caliendo, Giuseppe; Novellino, Ettore; Silipo, C.; Vittoria, A.. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 43:2(1988), pp. 141-151.
Structure-activity relationships for the auxin-like activity of benzotriazole derivatives
CALIENDO, GIUSEPPE;NOVELLINO, ETTORE;
1988
Abstract
On the basis of a previous equation correlating structural features and auxin-like activity, new sets of benzotriazole derivs. bearing in the position 1 or 2 a cycloalkyl residue, or substituents such as -CH(CH3)(CH2)n-COR', -CH(COR')(CH2)n-CH3, and -C(CH3)2 COR' (R' = OH, OEt; NH2) were prepd. and tested. An overall correlative equation which accommodates all the 106 benzotriazole derivs. was developed. Evidently, the bulkiness rather than asym. of the carbon attached to the heteroring nitrogen was responsible for extra activity. Moreover, structural features such as branching and -COR' group play an additive role only when the component parts of the N-substituent are properly structured.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
