IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS.
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome / Henström, M., Diekmann, L., Bonfiglio, F., Hadizadeh, F., Kuech, E.M., von Köckritz Blickwede, M., Thingholm, L.B., Zheng, T., Assadi, G., Dierks, C., Heine, M., Philipp, U., Distl, O., Money, M.E., Belheouane, M., Heinsen, F.A., Rafter, J., Nardone, G.A.P., Cuomo, R., Usai Satta, P., et al.. - In: GUT. - ISSN 0017-5749. - (2018), p. gutjnl-2016-312456. [10.1136/gutjnl-2016-312456]
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome
Bonfiglio, Ferdinando;NARDONE, GERARDO ANTONIO PIO;CUOMO, ROSARIO;
2018
Abstract
IBS is a common gut disorder of uncertain pathogenesis. Among other factors, genetics and certain foods are proposed to contribute. Congenital sucrase-isomaltase deficiency (CSID) is a rare genetic form of disaccharide malabsorption characterised by diarrhoea, abdominal pain and bloating, which are features common to IBS. We tested sucrase-isomaltase (SI) gene variants for their potential relevance in IBS.| File | Dimensione | Formato | |
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2016 - Functional variants in the sucrase–isomaltase gene in IBS Gut-2016.pdf
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