Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs / Hughes, Catherine E; Benson, Robert A; Bedaj, Marija; Maffia, Pasquale. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - 7:(2016), pp. 481-488. [10.3389/fimmu.2016.00481]
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
MAFFIA, PASQUALE
Ultimo
Project Administration
2016
Abstract
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.| File | Dimensione | Formato | |
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