An extensive phytochem. anal. of the polar exts. from bulbs of Welsh onion Allium fistulosum L. led to the isolation of nine saponins, four of them, named fistulosaponins G (1a/1b), H (2), I (3a/3b), and J (4), have never been reported previously. Fistulosaponins G and I were isolated as a couple of isomers in equil. On the basis of 2D NMR and mass spectrometry data, the structure of the novel compds. were elucidated as (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (1a) with its 22α epimer (1b), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (2), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (3a) with its 22α epimer (3b), and (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (4). This is the first report of furostanol saponins in A. fistulosum bulbs. In addn., data on the antibacterial tests of the isolated saponins against Escherichia coli and Enterococcus faecalis are reported. [on SciFinder(R)]

Furostanol Saponins from the Bulbs of Welsh Onion, Allium fistulosum L / Zolfaghari, Behzad; Yazdiniapour, Zeinab; Sadeghi, Masoud; Troiano, Raffaele; Lanzotti, Virginia. - In: PLANTA MEDICA. - ISSN 0032-0943. - 82:17(2016), pp. Ahead of Print-1590. [10.1055/s-0042-120122]

Furostanol Saponins from the Bulbs of Welsh Onion, Allium fistulosum L

TROIANO, RAFFAELE;LANZOTTI, VIRGINIA
2016

Abstract

An extensive phytochem. anal. of the polar exts. from bulbs of Welsh onion Allium fistulosum L. led to the isolation of nine saponins, four of them, named fistulosaponins G (1a/1b), H (2), I (3a/3b), and J (4), have never been reported previously. Fistulosaponins G and I were isolated as a couple of isomers in equil. On the basis of 2D NMR and mass spectrometry data, the structure of the novel compds. were elucidated as (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (1a) with its 22α epimer (1b), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (2), (25R)-26-[(β-D-glucopyranosyl)oxy]-3β,22β-dihydroxyfurost-5-en-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (3a) with its 22α epimer (3b), and (25R)-26-[(β-D-glucopyranosyl)oxy]-3β-hydroxyfurost-5,20-dien-1β-yl O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside (4). This is the first report of furostanol saponins in A. fistulosum bulbs. In addn., data on the antibacterial tests of the isolated saponins against Escherichia coli and Enterococcus faecalis are reported. [on SciFinder(R)]
2016
Furostanol Saponins from the Bulbs of Welsh Onion, Allium fistulosum L / Zolfaghari, Behzad; Yazdiniapour, Zeinab; Sadeghi, Masoud; Troiano, Raffaele; Lanzotti, Virginia. - In: PLANTA MEDICA. - ISSN 0032-0943. - 82:17(2016), pp. Ahead of Print-1590. [10.1055/s-0042-120122]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/657188
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