Effectiveness of topical bonellin and sunlight for treatment of experimental rabbit mycoses

The photodynamic activity of bonellin has been investigated on rabbit superficial mycoses. The animals, experimentally infected with Trichophyton mentagrophytes, receveid topical applications of bonellin solution (100, 150 200 mg/ml) on the mycotic patches before the irradiation with a solar simulator (90J(cm2). Both bonellin application and irradiation were carried out once for each rabbit. The results for rabbits receveing 150 and 200 mg/ml of bonellin show that: 1)the microscopic and coltural examination, from samples collected 72 hours from the treatment, were negative and 2) after 9 days the animals appeared clinically and microbiologically recovered. The possible action mechanism is discussed.