The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways in tumorigenesis.
p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker / Missero, Caterina; Antonini, Dario. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - 137:2(2017), pp. 280-281-281. [10.1016/j.jid.2016.10.032]
p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker
MISSERO, Caterina
;ANTONINI, Dario
2017
Abstract
The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways in tumorigenesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
