BACKGROUND: A relationship between low levels of serum vitamin D and respiratory infections has been established. No study has examined the frequency and clinical relevance of vitamin D deficiency in patients with primary ciliary dyskinesia (PCD). METHODS: Vitamin D levels were measured in 22 PCD patients (7 females, 10.5 years, range, 2-34 years). In PCD, pulmonary function tests (PFTs), sputum microbiology, self-reported physical activity (PA) level, and quality of life (QoL) by means of the Saint George's Respiratory Questionnaire (SGRQ), were also assessed. RESULTS: Seventy-two percent of PCD patients were vitamin-D deficient-to-insufficient and 28% were sufficient. No differences in PFTs parameters were found between vitamin D deficiency-to-insufficiency and sufficiency groups. Patients with vitamin D deficiency-to-insufficiency had significantly higher SGRQ total scores, and thus poorer QoL (p = 0.03). Seventy-nine percent of PCD subjects had limitations in performing vigorous activities, and 53% performed less than 3 hours of PA per week. Vitamin D deficiency-to-insufficiency and sufficiency groups did not show any differences in age at PCD diagnosis or at onset of respiratory symptoms, BMI, atopy, current asthma or bronchiectasis. However, 79% of patients with bronchiectasis had vitamin D deficiency-to-insufficiency. No differences were found in the rate of positive sputum cultures and in the number of antibiotic courses between the two groups. CONCLUSIONS: Hypovitaminosis D is common in PCD patients, and is associated with poorer QoL. We recommend the assessment and treatment of hypovitaminosis D to be included in the routine management of PCD.

Hypovitaminosis D: a novel finding in primary ciliary dyskinesia / Mirra, Virginia; Caffarelli, Carlo; Maglione, Marco; Valentino, Rossella; Perruolo, Giuseppe; Mazzarella, Claudia; DI MICCO, LAIDA LISA; Montella, Silvia; Santamaria, Francesca. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 41:1(2015), p. 14. [10.1186/s13052-015-0119-5]

Hypovitaminosis D: a novel finding in primary ciliary dyskinesia

MIRRA, VIRGINIA;MAGLIONE, MARCO;VALENTINO, Rossella;PERRUOLO, GIUSEPPE;DI MICCO, LAIDA LISA;MONTELLA, SILVIA;SANTAMARIA, FRANCESCA
2015

Abstract

BACKGROUND: A relationship between low levels of serum vitamin D and respiratory infections has been established. No study has examined the frequency and clinical relevance of vitamin D deficiency in patients with primary ciliary dyskinesia (PCD). METHODS: Vitamin D levels were measured in 22 PCD patients (7 females, 10.5 years, range, 2-34 years). In PCD, pulmonary function tests (PFTs), sputum microbiology, self-reported physical activity (PA) level, and quality of life (QoL) by means of the Saint George's Respiratory Questionnaire (SGRQ), were also assessed. RESULTS: Seventy-two percent of PCD patients were vitamin-D deficient-to-insufficient and 28% were sufficient. No differences in PFTs parameters were found between vitamin D deficiency-to-insufficiency and sufficiency groups. Patients with vitamin D deficiency-to-insufficiency had significantly higher SGRQ total scores, and thus poorer QoL (p = 0.03). Seventy-nine percent of PCD subjects had limitations in performing vigorous activities, and 53% performed less than 3 hours of PA per week. Vitamin D deficiency-to-insufficiency and sufficiency groups did not show any differences in age at PCD diagnosis or at onset of respiratory symptoms, BMI, atopy, current asthma or bronchiectasis. However, 79% of patients with bronchiectasis had vitamin D deficiency-to-insufficiency. No differences were found in the rate of positive sputum cultures and in the number of antibiotic courses between the two groups. CONCLUSIONS: Hypovitaminosis D is common in PCD patients, and is associated with poorer QoL. We recommend the assessment and treatment of hypovitaminosis D to be included in the routine management of PCD.
2015
Hypovitaminosis D: a novel finding in primary ciliary dyskinesia / Mirra, Virginia; Caffarelli, Carlo; Maglione, Marco; Valentino, Rossella; Perruolo, Giuseppe; Mazzarella, Claudia; DI MICCO, LAIDA LISA; Montella, Silvia; Santamaria, Francesca. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - 41:1(2015), p. 14. [10.1186/s13052-015-0119-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/679914
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