Adipokines are known to play a relevant role in a number of cancer related molecular pathways. Adiponectin is a major adipokine with anti-inflammatory and beneficial metabolic actions. Furthermore, it has been shown to exert anti-carcinogenic effects in various tumor models and some clinical studies suggested an inverse relationship between circulating levels of adiponectin and an increased risk for development of malignancies. On the other hand, the cyclic AMP response element binding (CREB) transcription factor has been clearly linked to lung cancer.
Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells / Illiano, Michela; Nigro, Ersilia; Sapio, Luigi; Caiafa, Ilaria; Spina, Annamaria; Scudiero, Olga; Bianco, Andrea; Esposito, Sabrina; Mazzeo, Filomena; Pedone, Paolo Vincenzo; Daniele, Aurora; Naviglio, Silvio. - In: PULMONARY PHARMACOLOGY & THERAPEUTICS. - ISSN 1094-5539. - 45:(2017), pp. 114-120. [10.1016/j.pupt.2017.05.009]
Adiponectin down-regulates CREB and inhibits proliferation of A549 lung cancer cells
NIGRO, ERSILIA;SCUDIERO, OLGA;Daniele, Aurora;
2017
Abstract
Adipokines are known to play a relevant role in a number of cancer related molecular pathways. Adiponectin is a major adipokine with anti-inflammatory and beneficial metabolic actions. Furthermore, it has been shown to exert anti-carcinogenic effects in various tumor models and some clinical studies suggested an inverse relationship between circulating levels of adiponectin and an increased risk for development of malignancies. On the other hand, the cyclic AMP response element binding (CREB) transcription factor has been clearly linked to lung cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
