FKBP51 is a co-chaperone with isomerase activity, abundantly expressed in glioma. We previously identified a spliced isoform (FKBP51s) and highlighted a role for this protein in the upregulation of Programmed Death Ligand 1 (PD-L1) expression in melanoma. Because gliomas can express PD-L1 causing a defective host anti-tumoral immunity, we investigated whether FKBP51s was expressed in glioma and played a role in PD-L1 regulation in this tumour.
A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma / D'Arrigo, Paolo; Russo, Michele; Rea, Anna; Tufano, Martina; Guadagno, Elia; DEL BASSO DE CARO, Marialaura; Pacelli, Roberto; Hausch, Felix; Staibano, Stefania; Ilardi, Gennaro; Parisi, Silvia; Romano, MARIA FIAMMETTA; Romano, Simona. - In: ONCOTARGET. - ISSN 1949-2553. - 8:40(2017), pp. 1-21. [10.18632/oncotarget.19309]
A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma
D'ARRIGO, PAOLO;RUSSO, MICHELE;GUADAGNO, ELIA;DEL BASSO DE CARO, MARIALAURA;PACELLI, ROBERTO;STAIBANO, STEFANIA;ILARDI, GENNARO;PARISI, SILVIA;ROMANO, MARIA FIAMMETTA
;ROMANO, SIMONA
2017
Abstract
FKBP51 is a co-chaperone with isomerase activity, abundantly expressed in glioma. We previously identified a spliced isoform (FKBP51s) and highlighted a role for this protein in the upregulation of Programmed Death Ligand 1 (PD-L1) expression in melanoma. Because gliomas can express PD-L1 causing a defective host anti-tumoral immunity, we investigated whether FKBP51s was expressed in glioma and played a role in PD-L1 regulation in this tumour.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
