Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease.
Serum IGF-1 is associated with cognitive functions in early, drug-naïve Parkinson's disease / Picillo, Marina; Pivonello, Rosario; Santangelo, Gabriella; Pivonello, Claudia; Savastano, Riccardo; Auriemma, RENATA SIMONA; Amboni, Marianna; Scannapieco, Sara; Pierro, Angela; Colao, Annamaria; Barone, Paolo; Pellecchia, Maria Teresa. - In: PLOS ONE. - ISSN 1932-6203. - 12:10(2017), p. e0186508. [10.1371/journal.pone.0186508]
Serum IGF-1 is associated with cognitive functions in early, drug-naïve Parkinson's disease
PIVONELLO, ROSARIO;PIVONELLO, CLAUDIA;AURIEMMA, RENATA SIMONA;COLAO, ANNAMARIA;
2017
Abstract
Cognitive deficits are common in Parkinson's disease (PD) since the early stages and many patients eventually develop dementia. Yet, occurrence of dementia in PD is unpredictable. Evidence supports the hypothesis that insulin-like growth factor-1 (IGF-1) is involved in cognitive deficits. Our aim was to evaluate the relationship between serum IGF-1 levels and neuropsychological scores in a large cohort of drug-naïve PD patients during the earliest stages of the disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
