Klinefelter Syndrome (KS) is the most common sex chromosome aneuploidy (47,XXY) and cause of male hypergonadotropic hypogonadism. It is characterized by an extreme clinical heterogeneity in presentation, including infertility, hypogonadism, language delay, metabolic comorbidities, and neurocognitive and psychiatric disorders. Since testosterone is known to have organizational, neurotrophic and neuroprotective effects on brain, the condition of primary hypogonadism could play a role. Moreover, given that KS subjects have an additional X, genes on the extra-chromosome could also exert a significant impact. The aim of this narrative review is to analyze the available literature on the relationship between KS and neuropsychiatric disorders.
Neuropsychiatric Aspects in Men with Klinefelter Syndrome / Giagulli, Vito Angelo; Capone, Beatrice; Castellana, Marco; Salzano, Ciro; Fisher, Alessandra; de Angelis, Cristina; Pivonello, Rosario; Colao, Annamaria; Pasquali, Daniela; Maggi, Mario; Triggiani, Vincenzo. - In: ENDOCRINE, METABOLIC & IMMUNE DISORDERS. DRUG TARGETS. - ISSN 2212-3873. - (2018). [10.2174/1871530318666180703160250]
Neuropsychiatric Aspects in Men with Klinefelter Syndrome
Salzano, Ciro;de Angelis, Cristina;Pivonello, Rosario;Colao, Annamaria;Pasquali, Daniela;MAGGI, MARIO;
2018
Abstract
Klinefelter Syndrome (KS) is the most common sex chromosome aneuploidy (47,XXY) and cause of male hypergonadotropic hypogonadism. It is characterized by an extreme clinical heterogeneity in presentation, including infertility, hypogonadism, language delay, metabolic comorbidities, and neurocognitive and psychiatric disorders. Since testosterone is known to have organizational, neurotrophic and neuroprotective effects on brain, the condition of primary hypogonadism could play a role. Moreover, given that KS subjects have an additional X, genes on the extra-chromosome could also exert a significant impact. The aim of this narrative review is to analyze the available literature on the relationship between KS and neuropsychiatric disorders.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
