Infections by multidrug-resistant (MDR) bacteria are a worrisome phenomenon in hematological patients. Data on the incidence of MDR colonization and related bloodstream infections (BSIs) in haematological patients are scarce. A multicentric prospective observational study was planned in 18 haematological institutions during a 6-month period. All patients showing MDR rectal colonization as well as occurrence of BSI at admission were recorded. One-hundred forty-four patients with MDR colonization were observed (6.5% of 2226 admissions). Extended spectrum beta-lactamase (ESBL)-producing (ESBL-P) enterobacteria were observed in 64/144 patients, carbapenem-resistant (CR) Gram-negative bacteria in 85/144 and vancomycin-resistant enterococci (VREs) in 9/144. Overall, 37 MDR-colonized patients (25.7%) developed at least one BSI; 23 of them (62.2%, 16% of the whole series) developed BSI by the same pathogen (MDRrel BSI), with a rate of 15.6% (10/64) for ESBL-P enterobacteria, 14.1% (12/85) for CR Gram-negative bacteria and 11.1% (1/9) for VRE. In 20/23 cases, MDRrel BSI occurred during neutropenia. After a median follow-up of 80 days, 18 patients died (12.5%). The 3-month overall survival was significantly lower for patients colonized with CR Gram-negative bacteria (83.6%) and VRE (77.8%) in comparison with those colonized with ESBL-P enterobacteria (96.8%). CR-rel BSI and the presence of a urinary catheter were independent predictors of mortality. MDR rectal colonization occurs in 6.5% of haematological inpatients and predicts a 16% probability of MDRrel BSI, particularly during neutropenia, as well as a higher probability of unfavourable outcomes in CR-rel BSIs. Tailored empiric antibiotic treatment should be decided on the basis of colonization.

Bloodstream infections in haematological cancer patients colonized by multidrug-resistant bacteria / Cattaneo, C.; Di Blasi, R.; Skert, C.; Candoni, A.; Martino, B.; Di Renzo, N.; Delia, M.; Ballanti, S.; Marchesi, F.; Mancini, V.; Orciuolo, E.; Cesaro, S.; Prezioso, L.; Fanci, R.; Nadali, G.; Chierichini, A.; Facchini, L.; Picardi, M.; Malagola, M.; Orlando, V.; Trecarichi, E. M.; Tumbarello, M.; Aversa, F.; Rossi, G.; Pagano, L.; Passi, Angela; Gramegna, Doriana; Russo, Domenico; Lazzarotto, Davide; Rotilio, Domenico; De Paolis, Maria Rosaria; Simonetti, Edoardo; Innocente, Maria Alessandra; Spadea, Antonio; Mazziotta, Francesco; Pegoraro, Anna; Spolzino, Angelica; Turri, Gloria; Veggia, Barbara. - In: ANNALS OF HEMATOLOGY. - ISSN 0939-5555. - 97:9(2018), pp. 1717-1726. [10.1007/s00277-018-3341-6]

Bloodstream infections in haematological cancer patients colonized by multidrug-resistant bacteria

Picardi, M.;
2018

Abstract

Infections by multidrug-resistant (MDR) bacteria are a worrisome phenomenon in hematological patients. Data on the incidence of MDR colonization and related bloodstream infections (BSIs) in haematological patients are scarce. A multicentric prospective observational study was planned in 18 haematological institutions during a 6-month period. All patients showing MDR rectal colonization as well as occurrence of BSI at admission were recorded. One-hundred forty-four patients with MDR colonization were observed (6.5% of 2226 admissions). Extended spectrum beta-lactamase (ESBL)-producing (ESBL-P) enterobacteria were observed in 64/144 patients, carbapenem-resistant (CR) Gram-negative bacteria in 85/144 and vancomycin-resistant enterococci (VREs) in 9/144. Overall, 37 MDR-colonized patients (25.7%) developed at least one BSI; 23 of them (62.2%, 16% of the whole series) developed BSI by the same pathogen (MDRrel BSI), with a rate of 15.6% (10/64) for ESBL-P enterobacteria, 14.1% (12/85) for CR Gram-negative bacteria and 11.1% (1/9) for VRE. In 20/23 cases, MDRrel BSI occurred during neutropenia. After a median follow-up of 80 days, 18 patients died (12.5%). The 3-month overall survival was significantly lower for patients colonized with CR Gram-negative bacteria (83.6%) and VRE (77.8%) in comparison with those colonized with ESBL-P enterobacteria (96.8%). CR-rel BSI and the presence of a urinary catheter were independent predictors of mortality. MDR rectal colonization occurs in 6.5% of haematological inpatients and predicts a 16% probability of MDRrel BSI, particularly during neutropenia, as well as a higher probability of unfavourable outcomes in CR-rel BSIs. Tailored empiric antibiotic treatment should be decided on the basis of colonization.
2018
Bloodstream infections in haematological cancer patients colonized by multidrug-resistant bacteria / Cattaneo, C.; Di Blasi, R.; Skert, C.; Candoni, A.; Martino, B.; Di Renzo, N.; Delia, M.; Ballanti, S.; Marchesi, F.; Mancini, V.; Orciuolo, E.; Cesaro, S.; Prezioso, L.; Fanci, R.; Nadali, G.; Chierichini, A.; Facchini, L.; Picardi, M.; Malagola, M.; Orlando, V.; Trecarichi, E. M.; Tumbarello, M.; Aversa, F.; Rossi, G.; Pagano, L.; Passi, Angela; Gramegna, Doriana; Russo, Domenico; Lazzarotto, Davide; Rotilio, Domenico; De Paolis, Maria Rosaria; Simonetti, Edoardo; Innocente, Maria Alessandra; Spadea, Antonio; Mazziotta, Francesco; Pegoraro, Anna; Spolzino, Angelica; Turri, Gloria; Veggia, Barbara. - In: ANNALS OF HEMATOLOGY. - ISSN 0939-5555. - 97:9(2018), pp. 1717-1726. [10.1007/s00277-018-3341-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/722183
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