Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent and debilitating skin disease of the hair follicle, which usually occurs after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body. In psoriasis, a strong action on mTORC1 of etanercept, anti-TNF-a agent, has previously assessed. Here too, the difference in staining of P-S6K1 was observed in responder and non-responder patients.8 In conclusion, mTORC1 pathway is modulated by anti-TNF-a treatment, highlighting a possible new mechanism by which TNF-a inhibition improves HS.
Anti-TNF-α therapy modulates mTORC1 signalling in hidradenitis suppurativa / Balato, A; Caiazzo, G; Annunziata, Mc; Marasca, C; Scala, E; Cacciapuoti, S; Fabbrocini, G.. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 33:1(2019), pp. 43-45. [10.1111/jdv.15160]
Anti-TNF-α therapy modulates mTORC1 signalling in hidradenitis suppurativa
Balato A;Caiazzo G;Annunziata MC;Marasca C;Scala E;Cacciapuoti S;Fabbrocini G.
2019
Abstract
Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent and debilitating skin disease of the hair follicle, which usually occurs after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body. In psoriasis, a strong action on mTORC1 of etanercept, anti-TNF-a agent, has previously assessed. Here too, the difference in staining of P-S6K1 was observed in responder and non-responder patients.8 In conclusion, mTORC1 pathway is modulated by anti-TNF-a treatment, highlighting a possible new mechanism by which TNF-a inhibition improves HS.| File | Dimensione | Formato | |
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