This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.
HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation? / Amato, Jussara; Madanayake, Thushara W.; Iaccarino, Nunzia; Novellino, Ettore; Randazzo, Antonio; Hurley, Laurence H.; Pagano, Bruno. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 54:68(2018), pp. 9442-9445. [10.1039/c8cc03614d]
HMGB1 binds to the KRAS promoter G-quadruplex: A new player in oncogene transcriptional regulation?
Amato, JussaraPrimo
;Iaccarino, Nunzia;Novellino, Ettore;Randazzo, Antonio;Pagano, Bruno
Ultimo
2018
Abstract
This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.| File | Dimensione | Formato | |
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