Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.
Cannabidiol: State of the art and new challenges for therapeutic applications / Pisanti, Simona; Malfitano, ANNA MARIA; Ciaglia, Elena; Lamberti, Anna; Ranieri, Roberta; Cuomo, Gaia; Abate, Mario; Faggiana, Giorgio; Proto, MARIA CHIARA; Fiore, Donatella; Laezza, Chiara; Bifulco, Maurizio. - In: PHARMACOLOGY & THERAPEUTICS. - ISSN 0163-7258. - 175:(2017), pp. 133-150. [10.1016/j.pharmthera.2017.02.041]
Cannabidiol: State of the art and new challenges for therapeutic applications
MALFITANO, ANNA MARIAMembro del Collaboration Group
;LAEZZA, CHIARAMembro del Collaboration Group
;BIFULCO, Maurizio
2017
Abstract
Over the past years, several lines of evidence support a therapeutic potential of Cannabis derivatives and in particular phytocannabinoids. Δ9-THC and cannabidiol (CBD) are the most abundant phytocannabinoids in Cannabis plants and therapeutic application for both compounds have been suggested. However, CBD is recently emerging as a therapeutic agent in numerous pathological conditions since devoid of the psychoactive side effects exhibited instead by Δ9-THC. In this review, we highlight the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function. Furthermore, the therapeutic potential of cannabidiol is also highlighted, in particular in nuerological diseases and cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
