Non-invasive real-time in-vivo monitoring of insulin absorption from subcutaneous tissues

A non-invasive measuring system for assessing in-vivo and in real time the individual rate of absorption of insulin from subcutaneous tissue has been developed at University of Naples Federico II [1]. In this paper, the method is proved to be a sound reference for insulin therapy. In particular, the proposed measurement system allows to assess if the insulin injected in subcutis is actually flowing into patients bloodstream in due course to achieve the treatment goal. For proving this principle, the previously prototyped and validated portable measuring medical device (DUSM, Drug Under Skin Meter) was revised and an experimental campaign was carried out in order to prove the suitability for insulin therapy.