Furolignan-type natural products, possessing important biological properties, have been synthesized from a commercially available furan. The elaborated synthetic strategy is based on an innovative Friedel-Crafts reaction starting from an alcohol or a carboxylic acid and triflic anhydride as promoter. Through this synthetic strategy, furolignans having two different aryl groups have been obtained. The products have been evaluated for their antimicrobial properties on Gram positive and Gram negative bacteria, in order to compare their biological activities with those of natural analogues.
Synthesis of 3-benzoyl-4-benzylfurans structural related to furolignans / Tufano, Immacolata; Iesce, Maria Rosaria; Buommino, Elisabetta; Cermola, Flavio; Della Greca, Marina. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - 34:15(2020), pp. 2109-2115. [10.1080/14786419.2019.1576040]
Synthesis of 3-benzoyl-4-benzylfurans structural related to furolignans
Tufano, Immacolata;Iesce, Maria Rosaria;Buommino, Elisabetta;Cermola, Flavio;Della Greca, Marina
2020
Abstract
Furolignan-type natural products, possessing important biological properties, have been synthesized from a commercially available furan. The elaborated synthetic strategy is based on an innovative Friedel-Crafts reaction starting from an alcohol or a carboxylic acid and triflic anhydride as promoter. Through this synthetic strategy, furolignans having two different aryl groups have been obtained. The products have been evaluated for their antimicrobial properties on Gram positive and Gram negative bacteria, in order to compare their biological activities with those of natural analogues.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
