The n-butanolic extract, from an Iranian specimen of Nepeta asterotricha Rech. f. (NABE), displayed anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated J774A.1 macrophages, which reduced nitrites and cytokines production. Bioassay guided fractionation of the extract led to the isolation of four iridoid glycosides, including a new one known as nepetamoside (1), one hexenyl-diglycoside, and some polyphenol and flavonoid components. None of the isolated iridoid components displayed significant effects on nitrites formation in an in vitro LPS-induced model of inflammation, thus suggesting that the plant anti-inflammatory effect is probably due to a synergistic action among its constituents
Phytochemical and biological studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside / Mostafa Goldansaz, Seyed; Festa, Carmen; Pagano, Ester; DE MARINO, Simona; Finamore, Claudia; Parisi, OLGA ALESSANDRA; Borrelli, Francesca; Sonboli, Ali; D'Auria, MARIA VALERIA. - In: MOLECULES. - ISSN 1420-3049. - 24:9(2019), pp. 1684-1695. [10.3390/molecules24091684]
Phytochemical and biological studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside
Carmen FestaSecondo
;Ester Pagano;Simona De Marino;Claudia Finamore;Olga Alessandra Parisi;Francesca Borrelli;Maria Valeria D’AuriaUltimo
2019
Abstract
The n-butanolic extract, from an Iranian specimen of Nepeta asterotricha Rech. f. (NABE), displayed anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated J774A.1 macrophages, which reduced nitrites and cytokines production. Bioassay guided fractionation of the extract led to the isolation of four iridoid glycosides, including a new one known as nepetamoside (1), one hexenyl-diglycoside, and some polyphenol and flavonoid components. None of the isolated iridoid components displayed significant effects on nitrites formation in an in vitro LPS-induced model of inflammation, thus suggesting that the plant anti-inflammatory effect is probably due to a synergistic action among its constituentsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
