Both normal gray matter atrophy and brain tissue relaxation rates, in addition to total lesion volume, have shown significant correlations with cognitive test scores in multiple sclerosis (MS). Aim of the study was to assess the relative contributions of macro- and microstructural changes of both normal and abnormal brain tissues, probed, respectively, by their volumes and relaxation rates, to the cognitive status and physical disability of MS patients.
Brain tissue volumes and relaxation rates in multiple sclerosis: implications for cognitive impairment / Megna, Rosario; Alfano, Bruno; Lanzillo, Roberta; Costabile, Teresa; Comerci, Marco; Vacca, Giovanni; Carotenuto, Antonio; Moccia, Marcello; Servillo, Giuseppe; Prinster, Anna; Brescia Morra, Vincenzo; Quarantelli, Mario. - In: JOURNAL OF NEUROLOGY. - ISSN 0340-5354. - 266:2(2019), pp. 361-368-368. [10.1007/s00415-018-9139-6]
Brain tissue volumes and relaxation rates in multiple sclerosis: implications for cognitive impairment
Lanzillo, Roberta;Costabile, Teresa;Carotenuto, Antonio;Moccia, Marcello;Servillo, Giuseppe;Prinster, Anna;Brescia Morra, Vincenzo;
2019
Abstract
Both normal gray matter atrophy and brain tissue relaxation rates, in addition to total lesion volume, have shown significant correlations with cognitive test scores in multiple sclerosis (MS). Aim of the study was to assess the relative contributions of macro- and microstructural changes of both normal and abnormal brain tissues, probed, respectively, by their volumes and relaxation rates, to the cognitive status and physical disability of MS patients.| File | Dimensione | Formato | |
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