Hepatocyte polarity is essential for the development of bile canaliculi and for safely transporting bile and waste products from the liver. Functional studies of autologous mutated proteins in the context of the polarized hepatocyte have been challenging because of the lack of appropriate cell models. The aims of this study were to obtain a patient-specific hepatocyte model that recapitulated hepatocyte polarity and to employ this model to study endogenous mutant proteins in liver diseases that involve hepatocyte polarity.
Pluripotent stem cell-derived bile canaliculi-forming hepatocytes to study genetic liver diseases involving hepatocyte polarity / Overeem, A. W.; Klappe, K.; Parisi, S.; Kloters-Planchy, P.; Matakovic, L.; du Teil Espina, M.; Drouin, C. A.; Weiss, K. H.; van IJzendoorn, S. C. D.. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 71:2(2019), pp. 344-356. [10.1016/j.jhep.2019.03.031]
Pluripotent stem cell-derived bile canaliculi-forming hepatocytes to study genetic liver diseases involving hepatocyte polarity
Parisi S.Membro del Collaboration Group
;
2019
Abstract
Hepatocyte polarity is essential for the development of bile canaliculi and for safely transporting bile and waste products from the liver. Functional studies of autologous mutated proteins in the context of the polarized hepatocyte have been challenging because of the lack of appropriate cell models. The aims of this study were to obtain a patient-specific hepatocyte model that recapitulated hepatocyte polarity and to employ this model to study endogenous mutant proteins in liver diseases that involve hepatocyte polarity.| File | Dimensione | Formato | |
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