Among the three enzymes involved in the transsulfuration pathway, only cystathionine β-synthase (CBS) converts L-cysteine into L-serine and H2 S. L-serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl-CoA by the action of serine palmitoyltransferase (SPT). Here, we have investigated if L-serine contributes to the vasorelaxant effect.
L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway / Mitidieri, E.; Gurgone, D.; Caiazzo, E.; Tramontano, T.; Cicala, C.; Sorrentino, R.; d'Emmanuele di Villa Bianca, R.. - In: BRITISH JOURNAL OF PHARMACOLOGY. - ISSN 0007-1188. - 177:4(2020), pp. 734-744. [10.1111/bph.14654]
L-cysteine/cystathionine-β-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway
Mitidieri E.Primo
;Gurgone D.;Caiazzo E.;Cicala C.;Sorrentino R.
Penultimo
;d'Emmanuele di Villa Bianca R.Ultimo
2020
Abstract
Among the three enzymes involved in the transsulfuration pathway, only cystathionine β-synthase (CBS) converts L-cysteine into L-serine and H2 S. L-serine is also involved in the de novo sphingolipid biosynthesis through a condensation with palmitoyl-CoA by the action of serine palmitoyltransferase (SPT). Here, we have investigated if L-serine contributes to the vasorelaxant effect.| File | Dimensione | Formato | |
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L‐cysteine_cystathionine‐β‐synthase‐induced relaxation in mouse aorta involves a L‐serine_sphingosine‐1‐phosphate_NO pathway.pdf
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