The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria.
Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors / Esposito, Anna.; De Gregorio, Eliana.; De Fenza, Maria.; D'Alonzo, Daniele.; Satawani, A.; Guaragna, A.. - In: RSC ADVANCES. - ISSN 2046-2069. - 9:37(2019), pp. 21519-21524. [10.1039/c9ra03673c]
Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors
Esposito Anna.;De Gregorio Eliana.;De Fenza Maria.;D'Alonzo Daniele.;Guaragna A.
2019
Abstract
The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria.File in questo prodotto:
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