G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deemed to be a promising therapeutic approach. Herein is reported a proof of principle study on the use of nano differential scanning fluorimetry for a rapid and accurate analysis of G4-stabilizing ligands, exploiting the fluorescence properties of a 2-aminopurine modified G4-forming oligonucleotide.
Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry / Pagano, Bruno; Iaccarino, Nunzia; Di Porzio, Anna; Randazzo, Antonio; Amato, Jussara. - In: ANALYST. - ISSN 0003-2654. - 144:22(2019), pp. 6512-6516. [10.1039/c9an01463b]
Screening of DNA G-quadruplex stabilizing ligands by nano differential scanning fluorimetry
Pagano, BrunoPrimo
;Iaccarino, Nunzia;Di Porzio, Anna;Randazzo, Antonio;Amato, Jussara
Ultimo
2019
Abstract
G-quadruplex (G4) nucleic acid structures are involved in a number of different diseases and their drug-induced stabilization is deemed to be a promising therapeutic approach. Herein is reported a proof of principle study on the use of nano differential scanning fluorimetry for a rapid and accurate analysis of G4-stabilizing ligands, exploiting the fluorescence properties of a 2-aminopurine modified G4-forming oligonucleotide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
