Kv7.4, a voltage-dependent potassium channel expressed throughout the vasculature, controls arterial contraction and is compromised in hypertension by an unknown mechanism. MicroRNAs (miRs) are post-transcriptional regulators of protein production and are altered in disease states such as hypertension. We investigated whether miRs regulate Kv7.4 expression.
MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension / Carr, G.; Barrese, V.; Stott, J. B.; Povstyan, O. V.; Jepps, T. A.; Figueiredo, H. B.; Zheng, D.; Jamshidi, Y.; Greenwood, I. A.. - In: CARDIOVASCULAR RESEARCH. - ISSN 0008-6363. - 112:2(2016), pp. 581-589. [10.1093/cvr/cvw177]
MicroRNA-153 targeting of KCNQ4 contributes to vascular dysfunction in hypertension
Barrese V.Co-primo
;
2016
Abstract
Kv7.4, a voltage-dependent potassium channel expressed throughout the vasculature, controls arterial contraction and is compromised in hypertension by an unknown mechanism. MicroRNAs (miRs) are post-transcriptional regulators of protein production and are altered in disease states such as hypertension. We investigated whether miRs regulate Kv7.4 expression.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
