HER2-positive (+) breast cancers, defined by HER2 overexpression and/or amplification, are often addicted to HER2 to maintain their malignant phenotype. Yet, some HER2+ tumors do not benefit from anti-HER2 therapy. We hypothesize that HER2 amplification levels and PI3K pathway activation are key determinants of response to HER2-targeted treatments without chemotherapy.
A combinatorial biomarker predicts pathologic complete response to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2+ breast cancer / De Angelis, C., Veeraraghavan, J., Mao, R., Wang, T., Herrera, S., Pavlick, A.C., Contreras, A., Nuciforo, P., Mayer, I.A., Forero, A., Nanda, R., Goetz, M.P., Chang, J.C., Wolff, A.C., Krop, I.E., Fuqua, S.A.W., Prat, A., Hilsenbeck, S.G., Weigelt, B., Reis-Filho, J.S., et al.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 30:6(2019), pp. 927-933. [10.1093/annonc/mdz076]
A combinatorial biomarker predicts pathologic complete response to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2+ breast cancer
De Angelis C.Co-primo
;
2019
Abstract
HER2-positive (+) breast cancers, defined by HER2 overexpression and/or amplification, are often addicted to HER2 to maintain their malignant phenotype. Yet, some HER2+ tumors do not benefit from anti-HER2 therapy. We hypothesize that HER2 amplification levels and PI3K pathway activation are key determinants of response to HER2-targeted treatments without chemotherapy.| File | Dimensione | Formato | |
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