To enlighten the involvement of PACAP/receptors system in the control of mammal testis, we investigated the expression of PACAP and the localization of PACAP and its receptors PAC1, VPAC1, and VPAC2 in the testis of Mus musculus. By molecular and immunohistochemical investigations, we highlighted that PACAP and its receptors are widely represented in germ cells of Mus testis, particularly in spermatocytes I, spermatids, and spermatozoa, strongly suggesting their involvement in spermatogenesis process. Moreover, for the first time in the adult mouse testis we highlighted that PACAP is present within Leydig cells, as PACAP receptors, confirming its involvement in the control of steroidogenesis in mouse.
Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors in Mus musculus testis / Prisco, M.; Rosati, L.; Morgillo, E.; Mollica, M. P.; Agnese, M.; Andreuccetti, P.; Valiante, S.. - In: GENERAL AND COMPARATIVE ENDOCRINOLOGY. - ISSN 0016-6480. - 286:(2020), pp. 113297-1-6. [10.1016/j.ygcen.2019.113297]
Pituitary adenylate cyclase-activating peptide (PACAP) and its receptors in Mus musculus testis
Prisco M.
Primo
;Rosati L.Secondo
;Mollica M. P.;Agnese M.;Andreuccetti P.;Valiante S.Ultimo
2020
Abstract
To enlighten the involvement of PACAP/receptors system in the control of mammal testis, we investigated the expression of PACAP and the localization of PACAP and its receptors PAC1, VPAC1, and VPAC2 in the testis of Mus musculus. By molecular and immunohistochemical investigations, we highlighted that PACAP and its receptors are widely represented in germ cells of Mus testis, particularly in spermatocytes I, spermatids, and spermatozoa, strongly suggesting their involvement in spermatogenesis process. Moreover, for the first time in the adult mouse testis we highlighted that PACAP is present within Leydig cells, as PACAP receptors, confirming its involvement in the control of steroidogenesis in mouse.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
