To evaluate the feasibility and sensitivity of multimodality PET/CT and MRI imaging for non-invasive characterization of brain microglial/macrophage activation occurring during the acute phase in a mouse model of relapsing remitting multiple sclerosis (RR-MS) using [18F]DPA-714, a selective radioligand for the 18-kDa translocator protein (TSPO), superparamagnetic iron oxide particles (SPIO), and ex vivo immunohistochemistry.
In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis / Coda, A R; Anzilotti, S; Boscia, F; Greco, A; Panico, M; Gargiulo, S; Gramanzini, M; Zannetti, A; Albanese, S; Pignataro, G; Annunziato, L; Salvatore, M; Brunetti, A; De Berardinis, P; Quarantelli, Mario; Palma, G; Pappatà, Sabina. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7070. - 48:(2021), pp. 40-52. [10.1007/s00259-020-04842-7]
In vivo imaging of CNS microglial activation/macrophage infiltration with combined [18F]DPA-714-PET and SPIO-MRI in a mouse model of relapsing remitting experimental autoimmune encephalomyelitis
Anzilotti, S;Boscia, F;Greco, A;Zannetti, A;Pignataro, G;Annunziato, L;Brunetti, A;Pappatà, Sabina
2021
Abstract
To evaluate the feasibility and sensitivity of multimodality PET/CT and MRI imaging for non-invasive characterization of brain microglial/macrophage activation occurring during the acute phase in a mouse model of relapsing remitting multiple sclerosis (RR-MS) using [18F]DPA-714, a selective radioligand for the 18-kDa translocator protein (TSPO), superparamagnetic iron oxide particles (SPIO), and ex vivo immunohistochemistry.| File | Dimensione | Formato | |
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