The need to identify molecular markers for early detection of laryngeal cancer prompted Kawasaki et al. to define a miRNA signature of tumor transformation and spreading. They showed the diagnostic and predictive potential of miR-133b and miR-449a, respectively, and demonstrated miR-449a-mediated suppression of the metastatic factors Notch1 and Notch2.
Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion / Kawasaki, H., Takeuchi, T., Ricciardiello, F., Lombardi, A., Biganzoli, E., Fornili, M., De Bortoli, D., Mesolella, M., Cossu, A.M., Scrima, M., Capasso, R., Falco, M., Motta, G., Motta, G., Testa, D., De Luca, S., Oliva, F., Abate, T., Mazzone, S., Misso, G., et al.. - In: MOLECULAR THERAPY NUCLEIC ACIDS. - ISSN 2162-2531. - 20:(2020), pp. 711-724. [10.1016/j.omtn.2020.04.006]
Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion
Ricciardiello F.;Lombardi A.;Mesolella M.;Motta G.;De Luca S.;Oliva F.;Abate T.;Mazzone S.;Misso G.;
2020
Abstract
The need to identify molecular markers for early detection of laryngeal cancer prompted Kawasaki et al. to define a miRNA signature of tumor transformation and spreading. They showed the diagnostic and predictive potential of miR-133b and miR-449a, respectively, and demonstrated miR-449a-mediated suppression of the metastatic factors Notch1 and Notch2.| File | Dimensione | Formato | |
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