The need to identify molecular markers for early detection of laryngeal cancer prompted Kawasaki et al. to define a miRNA signature of tumor transformation and spreading. They showed the diagnostic and predictive potential of miR-133b and miR-449a, respectively, and demonstrated miR-449a-mediated suppression of the metastatic factors Notch1 and Notch2.
Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion / Kawasaki, H.; Takeuchi, T.; Ricciardiello, F.; Lombardi, A.; Biganzoli, E.; Fornili, M.; De Bortoli, D.; Mesolella, M.; Cossu, A. M.; Scrima, M.; Capasso, R.; Falco, M.; Motta, G.; Motta, G.; Testa, D.; De Luca, S.; Oliva, F.; Abate, T.; Mazzone, S.; Misso, G.; Caraglia, M.. - In: MOLECULAR THERAPY NUCLEIC ACIDS. - ISSN 2162-2531. - 20:(2020), pp. 711-724. [10.1016/j.omtn.2020.04.006]
Definition of miRNA Signatures of Nodal Metastasis in LCa: miR-449a Targets Notch Genes and Suppresses Cell Migration and Invasion
Ricciardiello F.;Lombardi A.;Mesolella M.;Motta G.;De Luca S.;Oliva F.;Abate T.;Mazzone S.;Misso G.;
2020
Abstract
The need to identify molecular markers for early detection of laryngeal cancer prompted Kawasaki et al. to define a miRNA signature of tumor transformation and spreading. They showed the diagnostic and predictive potential of miR-133b and miR-449a, respectively, and demonstrated miR-449a-mediated suppression of the metastatic factors Notch1 and Notch2.| File | Dimensione | Formato | |
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