A visible-light-promoted three-component isocyanide-based synthesis of iminofurans is herein reported. The reaction proved to be general in scope and proceeds through a triple domino process. Control experiments with 18O-labeled water and TEMPO provided key mechanistic insights for delineating the reactivity paradigms crucial to design efficient photoredox isocyanide-based domino transformations.
Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans / Pelliccia, S.; Alfano, A. I.; Luciano, P.; Novellino, E.; Massarotti, A.; Tron, G. C.; Ravelli, D.; Giustiniano, M.. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 85:4(2020), pp. 1981-1990. [10.1021/acs.joc.9b02709]
Photocatalytic Isocyanide-Based Multicomponent Domino Cascade toward the Stereoselective Formation of Iminofurans
Pelliccia S.;Alfano A. I.;Luciano P.;Novellino E.;Giustiniano M.
2020
Abstract
A visible-light-promoted three-component isocyanide-based synthesis of iminofurans is herein reported. The reaction proved to be general in scope and proceeds through a triple domino process. Control experiments with 18O-labeled water and TEMPO provided key mechanistic insights for delineating the reactivity paradigms crucial to design efficient photoredox isocyanide-based domino transformations.| File | Dimensione | Formato | |
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