Purpose: The geometries used to conduct numerical simulations of the biomechanics of the human cornea are reconstructed from images of the physiological configuration of the system, which is not in a stress-free state because of the interaction with the surrounding tissues. If the goal of the simulation is a realistic estimation of the mechanical engagement of the system, it is mandatory to obtain a stress-free configuration to which the external actions can be applied. Methods: Starting from a unique physiological image, the search of the stress-free configuration must be based on methods of inverse analysis. Inverse analysis assumes the knowledge of one or more geometrical configurations and, chosen a material model, obtains the optimal values of the material parameters that provide the numerical configurations closest to the physiological images. Given the multiplicity of available material models, the solution is not unique. Results: Three exemplary material models are used in this study to demonstrate that the obtained, non-unique, stress-free configuration is indeed strongly dependent on both material model and on material parameters. Conclusion: The likeliness of recovering the actual stress-free configuration of the human cornea can be improved by using and comparing two or more imaged configurations of the same cornea.

On the recovery of the stress-free configuration of the human cornea / Montanino, Andrea; Pandolfi, Anna. - In: JOURNAL FOR MODELING IN OPHTHALMOLOGY. - ISSN 2468-3930. - 1:4(2020), pp. 11-33.

On the recovery of the stress-free configuration of the human cornea

Montanino, Andrea
Membro del Collaboration Group
;
Pandolfi, Anna
2020

Abstract

Purpose: The geometries used to conduct numerical simulations of the biomechanics of the human cornea are reconstructed from images of the physiological configuration of the system, which is not in a stress-free state because of the interaction with the surrounding tissues. If the goal of the simulation is a realistic estimation of the mechanical engagement of the system, it is mandatory to obtain a stress-free configuration to which the external actions can be applied. Methods: Starting from a unique physiological image, the search of the stress-free configuration must be based on methods of inverse analysis. Inverse analysis assumes the knowledge of one or more geometrical configurations and, chosen a material model, obtains the optimal values of the material parameters that provide the numerical configurations closest to the physiological images. Given the multiplicity of available material models, the solution is not unique. Results: Three exemplary material models are used in this study to demonstrate that the obtained, non-unique, stress-free configuration is indeed strongly dependent on both material model and on material parameters. Conclusion: The likeliness of recovering the actual stress-free configuration of the human cornea can be improved by using and comparing two or more imaged configurations of the same cornea.
2020
On the recovery of the stress-free configuration of the human cornea / Montanino, Andrea; Pandolfi, Anna. - In: JOURNAL FOR MODELING IN OPHTHALMOLOGY. - ISSN 2468-3930. - 1:4(2020), pp. 11-33.
File in questo prodotto:
File Dimensione Formato  
106-Article Text-962-1-10-20200616 (3).pdf

accesso aperto

Licenza: Dominio pubblico
Dimensione 1.07 MB
Formato Adobe PDF
1.07 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/813263
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact