Laparoscopic treatment of mixed adenoneuroendocrine cancer of right colon: case report and review of literature

Abstract Mixed adeno-neuroendocrine cancer (MANEC) term was introduced for the first time in WHO Classification of Gastrointestinal tumors in 2010. It represents a very rare neoplasm assessing about the 0.2% of all gastrointestinal cancer. The perioperative management is very challenging because of the poor knowledge of the biology of this cancer and the relative impossibility to make a diagnosis only by the biopsy during the colonoscopy. In this paper we present the case of a 83- year- old woman affected by right colon sited neoplasm with liver metastasis, which resulted to be a MANEC. The patient underwent to laparoscopic right colectomy and wedge resection of liver metastasis. The post-operative period was uneventful, and the patient was fit to be discharged at third post-operative day. A literature review about the etiology, diagnosis and treatment of right colon sited MANEC has been carried out and only eight papers about right sited MANEC have been found.