Acid hypersensitivity is claimed to be a symptomatic trigger in functional dyspepsia (FD); however, the neuroimmune pathway(s) and the mediators involved in this process have not been systematically investigated. Palmitoylethanolamide (PEA) is an endogenous compound, able to modulate nociception and inflammation, but its role in FD has never been assessed.
Impaired duodenal Palmitoylethanolamide release underlies acid-induced mast cells activation in Functional Dyspepsia / Sarnelli, Giovanni; Pesce, Marcella; Seguella, Luisa; Lu, Jie; Efficie, Eleonora; Tack, Jan; Elisa De Palma, Fatima Domenica; D'Alessandro, Alessandra; Esposito, Giuseppe. - In: CMGH. - ISSN 2352-345X. - 11:3(2021), pp. 841-855. [10.1016/j.jcmgh.2020.10.001]
Impaired duodenal Palmitoylethanolamide release underlies acid-induced mast cells activation in Functional Dyspepsia
Sarnelli, Giovanni
Primo
Supervision
;Pesce, Marcella;Efficie, Eleonora;Elisa De Palma, Fatima Domenica;
2021
Abstract
Acid hypersensitivity is claimed to be a symptomatic trigger in functional dyspepsia (FD); however, the neuroimmune pathway(s) and the mediators involved in this process have not been systematically investigated. Palmitoylethanolamide (PEA) is an endogenous compound, able to modulate nociception and inflammation, but its role in FD has never been assessed.| File | Dimensione | Formato | |
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