Circadian rhythm disruption is emerging as a risk factor for metabolic disorders and particularly, alterations in clock genes circadian expression have been shown to influence insulin sensitivity. Recently, the reciprocal interplay between the circadian clock machinery and HPA axis has been largely demonstrated: the circadian clock may control the physiological circadian endogenous glucocorticoids secretion and action; glucocorticoids, in turn, are potent regulator of the circadian clock and their inappropriate replacement has been associated with metabolic impairment. The aim of the current study was to investigate in vitro the interaction between the timing-of-the-day exposure to different hydrocortisone (HC) concentrations on muscle insulin sensitivity.

CORTISOL CIRCADIAN RHYTHM AND INSULIN RESISTANCE IN MUSCLE: EFFECT OF DOSING AND TIMING OF HYDROCORTISONE EXPOSURE ON INSULIN SENSITIVITY IN SYNCHRONIZED MUSCLE CELLS / Negri, Mariarosaria; Pivonello, Claudia; Simeoli, Chiara; Di Gennaro, Gilda; Venneri, Mary Anna; Sciarra, Francesca; Ferrigno, Rosario; de Angelis, Cristina; Sbardella, Emilia; De Martino, Maria Cristina; Colao, Annamaria; Isidori, Andrea M; Pivonello, Rosario. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - (2021). [10.1159/000512685]

CORTISOL CIRCADIAN RHYTHM AND INSULIN RESISTANCE IN MUSCLE: EFFECT OF DOSING AND TIMING OF HYDROCORTISONE EXPOSURE ON INSULIN SENSITIVITY IN SYNCHRONIZED MUSCLE CELLS

Negri, Mariarosaria;Pivonello, Claudia;Simeoli, Chiara;Di Gennaro, Gilda;Ferrigno, Rosario;de Angelis, Cristina;De Martino, Maria Cristina;Colao, Annamaria;Pivonello, Rosario
2021

Abstract

Circadian rhythm disruption is emerging as a risk factor for metabolic disorders and particularly, alterations in clock genes circadian expression have been shown to influence insulin sensitivity. Recently, the reciprocal interplay between the circadian clock machinery and HPA axis has been largely demonstrated: the circadian clock may control the physiological circadian endogenous glucocorticoids secretion and action; glucocorticoids, in turn, are potent regulator of the circadian clock and their inappropriate replacement has been associated with metabolic impairment. The aim of the current study was to investigate in vitro the interaction between the timing-of-the-day exposure to different hydrocortisone (HC) concentrations on muscle insulin sensitivity.
2021
CORTISOL CIRCADIAN RHYTHM AND INSULIN RESISTANCE IN MUSCLE: EFFECT OF DOSING AND TIMING OF HYDROCORTISONE EXPOSURE ON INSULIN SENSITIVITY IN SYNCHRONIZED MUSCLE CELLS / Negri, Mariarosaria; Pivonello, Claudia; Simeoli, Chiara; Di Gennaro, Gilda; Venneri, Mary Anna; Sciarra, Francesca; Ferrigno, Rosario; de Angelis, Cristina; Sbardella, Emilia; De Martino, Maria Cristina; Colao, Annamaria; Isidori, Andrea M; Pivonello, Rosario. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - (2021). [10.1159/000512685]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11588/823710
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 16
  • ???jsp.display-item.citation.isi??? 14
social impact